Asymptomatic individuals with coronavirus disease‑19 (COVID‑19) play a significant role in viral
transmission. These individuals are in the incubation period as healthy. Until now, the immune
responses of asymptomatic individuals have not been fully understood, and research evidence is very
lacking but few studies have indicated increases in the number of lymphocytes in the blood, giving
them strong cellular immunity. The blood of survivor’s silent carriers (asymptomatic individuals) may be
used as prophylaxis or/and treatment for patients. This review is focused on COVID‑19 transmission,
appropriate screening and testing, perspectives on immune responses in silent patients and their role
in the transmission of infection, the association of human leukocyte antigen haplotypes and COVID‑19
infection, and the perspectives on convalescence plasma and encouragement immunity hypothesis as
treatment and/or prophylaxis for COVID‑19 management. The current review can serve as an incentive
for researchers in the field of immunology, ecology, and virology. The review also rationally reports and
critically analyzes the information available by focusing on and identifying future steps and strategies
aimed at finding suitable solutions to COVID-19 management challenges by encouraging immunity
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