Investigating the Impact of Managerial Commitment, Employee Integration and Training and Learning in Implementing Total Quality Management in Selected Knowledge-Based Companies

Total quality management is a tool for net production that focuses on ensuring the production of goods that comply with technical specifications and achieve customer satisfaction and include attractive benefits that are considered by managers. The purpose of this study is to investigate managerial commitment, employee integration, training and learning in order to implement comprehensive …

Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells

Background: Most cancer cells exhibit increased glycolysis and use this metabolic pathway cell growth and proliferation. Targeting cancer cells’ metabolism is a promising strategy in inhibiting cancer cell progression. We used D-Mannoheptulose, a specific hexokinase inhibitor, to inhibit glycolysis to enhance the Newcastle disease virus anti-tumor effect. Methods: Human breast cancer cells were treated by …